The pharmaceutical company, Janssen, released an opioid pain-reliever, known as tramadol, over 25 years ago and in 2009 and the same company unveiled the brand, Nucynta, to the world.
Nucynta is a brand of analgesics belonging to the class of opiates and is indicated as being a stronger version of tramadol tablets, hence ideal for more severe cases. These pills are formulated with tapentadol 50 mg (they are available in other strengths as well) and are designed to be used for the treatment of acute and chronic pain.
You can buy tapentadol 225 mg, through an internet pharmacy, as the brand Tofrodol-XX. These tablets are created to contain 100 mg of the opioid pain reducing agent, in addition to 125 mg of carisoprodol. Carisoprodol is a muscle relaxant that is effective for the relief of musculoskeletal pain.
Tapentadol 50 mg is a pain-relieving medication used by men and women, all around the world. Clinical findings indicate that women are more prone to severe clinical pain and experience chronic discomfort on a greater scale than men. Moreover, the side effects associated with a therapeutic are often of higher incidence among females than their male counterparts as women are typically at an increased risk of adverse effects due to their hormonal profiling, lower body weights and other factors too.
Nucynta is an efficacious treatment, irrespective of gender, and is more effective than the opioid analgesic tramadol. Furthermore, these tablets have been shown to be safer, with a lower potential for abuse, than other NSAIDs (non-steroidal anti-inflammatory drugs) and traditional opiates.
Tofrodol-XX is a combination pain-reliever. It boasts the efficacy of the opioid painkiller in combination with the muscle relaxant properties of carisoprodol.
These tablets can be used for the treatment of diabetic neuropathic pain, which is the pain resulting from the nerve damaging effects of the disease, diabetes. In a randomised, controlled study conducted two years ago, Freo et. al, reviewed the efficacy of tapentadol 225 mg, and other dosages, in the relief of chronic neuropathic pain.
The findings suggested that to-date, the use of these pain tablets for the relief of neuropathic pain remains intact, but there is only preliminary evidence suggesting the efficacy of the opioid analgesic for the treatment of peripheral artery disease and Parkinson’s disease.
Anyone experiencing pain, acute or chronic, can buy tapentadol 50 mg as these painkillers were created for the efficacious management of pain symptoms. As they have been approved by the Food and Drug Administration (FDA) for the treatment of diabetic neuropathy, these pain-relieving tablets are commonly used by those with diabetes, who experience pain from nerve damage.
Moreover, in a more broad sense, a National Health and Nutrition Examination Survey, conducted by last year by the National Centre for Health Statistics, reported that at least 5.7% of adults used prescription opioid medications in the period of 2015 to 2018. Furthermore, the observations of this survey revealed that the prevalence of opioid use was higher among women than men and also increased with age.
Tapentadol 225 mg is a potent analgesic and even more so than tramadol tablets. The potency of Tofrodol-XX is significantly greater than the aforementioned opiate but is only about two to three times less than morphine, even though the opioid analgesic has a significantly lower binding affinity than morphine. Studies suggest that a 3.3 mg dosage of Nucynta may be equivalent to a 1 mg dose of the oral morphine therapeutic, in both patients who are native or tolerant to the medication (Holtsman and Hale, 2018).
In addition to its efficacy, these pain pills have also shown to be associated with a lower incidence of side effects than morphine and oxycodone (Holtsman and Hale, 2018).
Tapentadol 50 mg and tramadol are similar in their chemical composition. That is, these pain-relievers are both derived from the poppy plant and are classified as opiates. These opioid medications also function with similar mechanisms of action as they inhibit the reuptake of the neurotransmitter (chemical messenger) norepinephrine in a similar manner. However, tramadol inhibits the reuptake of the serotonin neurotransmitter three times more than Tofrodol-XX tablets.
This means that tramadol is generally associated with a higher incidence of serotonin-related toxicities and with inferior analgesia as well (Fudin and Boglish, 2016). However, the milder opiate still has its place when it comes to treating mild to moderate and moderately severe pain as some patients tolerate the medication well, and hence prefer it.
These painkiller tablets are typically well-tolerated but may be mildly associated with the following adverse effects:
This painkiller therapeutic may not directly inhibit the reuptake of serotonin but the increase of serotonin levels may be indirect, through the inhibition of the reuptake of norepinephrine. However, even though this medication does affect the levels of serotonin in the brain, the incidence of the serotonin syndrome side effect still remains a possibility, albeit with a low probability.
If you are looking for a pain management treatment, similar to the efficacy of the traditional opiates, you can purchase tapentadol 225 mg online here, script free. These pain tablets are available in branded or generic versions and can be bought as a single ingredient medication or a combination therapeutic, for greater strength with muscle relaxant properties.
Generic formulations are generally favored by most patients, as they are far cheaper than their branded counterparts. Furthermore, they are also equally effective as the brand name medicines as both versions contain the identical active ingredients.
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